Crystal structures of three newly synthesized flavanone hydrazones.

The crystal structures of racemic mixtures of three new flavanone-hydrazones in the centrosymmetric space group ( ), are reported. The structures of (±,)-'-[5,7-dihy-droxy-2-(4-hy-droxy-phen-yl)chroman-4-yl-idene]-2-(naphthalen-1-yl)acetohydrazide ethyl acetate monosolvate, CHNO·CHO, and of (±,)-'-[5,7-dihy-droxy-2-(4-hy-droxy-phen-yl)chroman-4-yl-idene]-4-hy-droxy-benzo-hydra-zide ethanol monosolvate, CHNO·CHOH, both exhibit an intra-molecular O-H⋯N and multiple inter-molecular O-H⋯O and C-H⋯O-type hydro-gen bonds. The third structure, that of (±,)-'-(6-methoxy-2-phenyl-chroman-4-yl-idene)-2-(naphthalen-1-yl-oxy)acetohydrazide, CHNO, has only one inter-molecular N-H⋯O-type hydrogen bond.

The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease.

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded α-synuclein, which is thought to play a critical role in the pathogenesis of the disease. Animal models of PD suggest that activation of Abelson tyrosine kinase (c-Abl) plays an essential role in the initiation and progression of α-synuclein pathology and initiates processes leading to degeneration of dopaminergic and nondopaminergic neurons.

External ventricular drain use is associated with functional outcome in aneurysmal subarachnoid hemorrhage.

Purpose: External ventricular drains (EVD) are commonly used in aneurysmal subarachnoid hemorrhage (aSAH) patients and can be life-saving by diverting cerebrospinal fluid. However, the overall relationship between EVD use and outcome is poorly understood.

Methods: In an exploratory analysis of an aSAH patient cohort, we examined EVD use in relation to modified Rankin Scale (mRS) at hospital discharge and at 6 months (unfavorable outcome = mRS > 2) using univariable and multivariable analyses.

Crystal structure of racemic (/,)-2-(4-hy-droxy-phen-yl)-4-(2-phenyl-hydrazin-1-yl-idene)chromane-5,7-diol ethanol monosolvate.

The crystal structure of racemic (/,)-2-(4-hy-droxy-phen-yl)-4-(2-phenyl-hydrazin-1-yl-idene)chromane-5,7-diol ethanol monosolvate, CHNO·CHO, in a centrosymmetric lattice is reported. The two racemates occupy the same position in the asymmetric unit - . Hydrogen bonds of the type O-H⋯C(π) in addition to typical C-H⋯O, O-H⋯O and O-H⋯N are identified.

Prognostic Value of a Structural Brain MRI Score in the Acute Phase of Aneurysmal Subarachnoid Hemorrhage: A Pilot Study.

Background/objective: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity and mortality despite advances in management. We evaluated the prognostic significance of a qualitative score using brain magnetic resonance imaging (MRI) features obtained early after aSAH.

Methods: Patients with aSAH were enrolled in a prospective observational cohort and underwent brain MRI during their acute hospitalization.