[SOME PHYSIOLOGICAL PROCESSES IN ISCHEMIC PENUMBRA OF THE BRAIN (REVIEW)].

The zone of penumbra in ischemic brain tissue lies below the local cerebral blood flow threshold for electrocortical silence but above that for anoxic depolarization and massive ionic dyshomeostasis. Conflicting data concerning the width of therapeutic window in which successful reperfusion of blood still is possible, are cited in this paper. The role of temperature in development of ischemic stroke is also considered.

[Effect of short-term manganese chloride intoxicatuion on anxiety and fear of young rats].

Manganese is an essential trace element for all living organisms. Though some neurological dysfunction take place during intoxication caused by excessive exposure of this metal. The goal of this research was to elucidate the emotional state, in particular anxiety and fear in three groups of young male rats.

Hyperthermia-induced morphological changes in cerebral tissue of the rat.

The sensitivity of cerebral tissue to hyperthermia, its immediate effect, manifested by histological changes and the role of local blood flow, blood rheological properties, and the possible role of free radicals in development of mentioned changes have been studied. Through the cranial window local area of cerebral surface was irrigated by artificial CSF heated up to 41, 43 or 45 degrees C. Serial brain coronal sections 50 microm thick were analyzed under light microscope.

Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride.

Morphological changes in neurons and the distributions of nerve and glial cells were studied, the glial index was calculated, and manganese (Mn) contents were determined in the caudate nucleus, the nucleus accumbens, the dorsal and ventral septal nuclei, and the frontoparietal areas of the cerebral cortex in the 40-day-old offspring of rats given different doses (10 and 20 mg/kg) of manganese chloride (MnCl2.4H2O) 15-20 days before pregnancy, during pregnancy, and for one month after parturition with the first portion of food. Mn poisoning increased Mn contents in the brains of rat pups, damaged a small proportion of neurons, and produced marked gliosis.

[Morphological changes and manganese level in the brain of rat pups subjected to subchronic manganese chloride intoxication].

The morphological alterations in the neurons together with the distribution of the neural and glial cells were studied, the glial index was calculated, and manganese level was determined in n. caudatus, n. accumbens septalis, n.