Publications by authors named "A Shteinfer"
Article Synopsis
- The study investigates potential biomarker proteins in chronic lymphocytic leukemia (CLL) by analyzing protein expression in blood cells from CLL patients compared to healthy individuals using advanced techniques like mass spectrometry and bioinformatics tools.
- A total of 1,360 proteins were identified with altered expressions in CLL, including two new proteins, DDX46 and AK3, that have not been previously linked to cancer.
- High levels of DDX46 were found to correlate with shorter patient survival, suggesting its potential as a prognostic marker, while other proteins related to metabolism and apoptosis (like VDAC1) showed strong links to disease progression and could predict disease odds with over 90% accuracy.
The voltage-dependent anion channel 1 (VDAC1), localized in the outer mitochondrial membrane, mediates metabolic cross-talk between the mitochondrion and the cytoplasm and thus serves a fundamental role in cell energy metabolism. VDAC1 also plays a key role in mitochondria-mediated apoptosis, interacting with anti-apoptotic proteins. Resistance of cancer cells to apoptosis involves quenching the mitochondrial apoptotic pathway by over-expression of anti-apoptotic/pro-survival hexokinase (HK) and Bcl-2 family proteins, proteins that mediate their anti-apoptotic activities via interaction with VDAC1.
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