HPV51-associated Leiomyosarcoma: A Novel Class of TP53/RB1-Wildtype Tumor With Predilection for the Female Lower Reproductive Tract.

Inactivating mutations in tumor suppressor genes TP53 and RB1 are considered central drivers in leiomyosarcomas (LMSs). In high-risk human papillomavirus (HPV)-related tumors, a similar functional outcome is achieved through oncoproteins E6 and E7, which inactivate the p53 and RB1 proteins, respectively. Here, we hypothesized that HPV infection could provide an alternative mechanism for tumorigenesis in a subset of TP53/RB1-wildtype LMS.

Occurrence of craniosynostosis in neonates exposed to cocaine and tobacco in utero.

The occurrence of craniosynostosis (premature closure of cranial sutures) has been reported to be 3 to 5 per 10,000 live births. The incidence is even lower among African-American infants. The District of Columbia General Hospital serves primarily the African-American population with approximately 2000 deliveries a year.

Sexually transmitted disease among adolescents in the juvenile justice system of the District of Columbia.

Disenfranchised youth are known to be at high risk for sexually transmitted infections. A study was conducted to validate the screening for sexually transmitted disease (STD) among adolescents under court jurisdiction, to characterize variables associated with STD among this group, and to contrast and compare the characteristics of STD among incarcerated youth as opposed to those in alternative court-sponsored facilities. Sixty teenagers referred to an outpatient adolescent clinic for court-ordered physical examination were tested for infection with syphilis.

African histoplasmosis presenting as a facial tumour in a child.

A case of African histoplasmosis with an unusual presentation in a 13-year old Nigerian school boy is described. The diagnosis was established by histological examination of biopsy material and treatment with amphotericin B was successfully undertaken.

Effects of levamisole on the immune responses of experimentally malnourished rats.

Levamisole (Ketrax), and anthelmintic drug commonly used in the tropics, has been found to restore the impaired spontaneous rosette-forming lymphocytes and delayed cutaneous hypersensitivity reactions in experimentally malnourished rats. It, however, has no effects on plaque-forming cells. The drug was also found to reconstitute the histologic integrity of the thymus in malnutrition.