Publications by authors named "A Shibamiya"
Human induced pluripotent stem cells (hiPSCs) are an invaluable tool to study molecular mechanisms on a human background. Culturing stem cells at an oxygen level different from their microenvironmental niche impacts their viability. To understand this mechanistically, dermal skin fibroblasts of 52 probands were reprogrammed into hiPSCs, followed by either hyperoxic (20 % O) or physioxic (5 % O) culture and proteomic profiling.
View Article and Find Full Text PDFCriteria for airflow obstruction (AFO) at one year after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in pulmonary function tests (PFTs) are more stringent than the bronchiolitis obliterans syndrome (BOS) criteria of the National Institutes of Health. This single-center, retrospective cohort study evaluated the clinical impact of the AFO criteria at any time after transplantation. In 132 patients who underwent allo-HSCT from 2006 to 2016, the 2-year cumulative incidence of AFO was 35.
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- - POEMS syndrome is a rare condition with symptoms including polyneuropathy and organ enlargement, primarily caused by issues with plasma cells; identifying monoclonal plasma cells (PCs) is crucial for diagnosis.
- - A new flow cytometry method called POEMS-flow was developed to improve the detection of monoclonal PCs compared to the previous MM-flow method, resulting in a higher detection rate (72.0% vs. 36.0%).
- - The study found that after treatment, the size of monoclonal cell clones significantly decreased, indicating that POEMS-flow not only aids in diagnosis but also helps assess treatment effectiveness.
TNF receptor associated factor 6 (TRAF6) is an E3 ubiquitin ligase that has been implicated in myeloid malignancies. Although altered TRAF6 expression is observed in human acute myeloid leukemia (AML), its role in the AML pathogenesis remains elusive. In this study, we showed that the loss of TRAF6 in AML cells significantly impairs leukemic function in vitro and in vivo, indicating its functional importance in AML subsets.
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