Publications by authors named "A Shet"
A Scoping Review on Sex and Gender Differences in the Adverse Health Outcomes of Individuals with Sickle Cell Trait.
Womens Health Rep (New Rochelle)
December 2024
Although there is an emerging body of evidence that addresses the adverse health outcomes of individuals with sickle cell trait (SCT), it is not clear if the findings are generalizable from a sex and gender perspective. The purpose of this scoping review was to complete an assessment of main concepts, identify knowledge gaps, and determine the potential value of conducting an eventual systematic review. The research question guiding this scoping review is: In SCT individuals with adverse health outcomes, what is known about sex and gender differences? We conducted a scoping review of research on SCT from 2016 to 2022 across five databases, with 36 research studies included in the review.
View Article and Find Full Text PDFThe goal of this study is to identify non-invasive optical hemodynamic biomarkers that can index laboratory hematology measurements in sickle cell disease (SCD). We acquired frequency-domain NIRS (FD-NIRS) and diffuse correlation spectroscopy (DCS) data from the forearms and foreheads of 17 participants in a randomized, double-blind, placebo-controlled trial evaluating effects of isoquercetin (IQ) on thromboinflammation in SCD. We observed multiple, significant correlations between optical and hematology biomarkers including cerebral tissue oxygen saturation (StO) and hematocrit (HCT); oxyhemoglobin ([OHb]) recovery rate and intercellular adhesion molecule 1 (ICAM-1); and blood flow index (BFI) reperfusion rate and coagulation index (CI).
View Article and Find Full Text PDFArticle Synopsis
- Child development assessment tests are crucial for educational placement and identifying cognitive weaknesses, but most research has been limited to high-income countries, making adaptation to other contexts challenging.
- As part of a study on the impact of childhood vaccines in rural Haryana, India, researchers aimed to assess the feasibility of enrolling local children and conducting development assessments for kids aged 18 months to 8 years.
- A rigorous seven-step adaptation process was developed to culturally and contextually tailor three assessment tests, which included translation, back-translation, iterative adaptation, and field-testing to ensure validity and relevance in the rural setting.
Article Synopsis
- - The P-Process offers a structured, five-step framework for improving vaccination strategies by focusing on social and behavioral factors, integrating with health systems, and collaborating with local experts to effectively address public health challenges.
- - A multi-faceted communication intervention was created in India and Nigeria to boost vaccine uptake among hospitalized children, involving interviews with caregivers, co-development workshops, and piloting of materials with various stakeholders.
- - Following the P-Process, feedback from caregivers and healthcare workers indicated that their communication improved, and caregivers felt their concerns about vaccination were addressed, demonstrating a successful approach to enhancing vaccine uptake.
Background Surgical site infection in colon surgery is associated with significant cost and increased length of hospital stay. Recently, there has been interest in the use of pulsed lavage to reduce the risk of surgical site infection in contaminated wounds. Although increasingly used and gaining popularity, its effectiveness in elective colorectal surgery has been poorly documented.
View Article and Find Full Text PDF