Number and dynamics of micronuclei and near-tetraploidy predict prognosis in childhood acute leukaemia.

Objectives: This study aims to identify factors possibly contributing to complications in children with acute leukaemia. Despite diverse etiological causes, similar processes trigger the process of cell malignancy. Genomic instability has received considerable attention in this context.

[SOME CYTOGENETIC PARAMETERS IN CHILDREN WITH ACUTE LEUKEMIA ASSOCIATED WITH COVID-19 INFECTION (CASE REPORTS)].

There are data about 6 cases of acute leukemia in children who have been diagnosed with COVID-19 infection 1-1,5 months before, or at the same time. In 5 patients lymphoblastic and in one monoblastic acute leukemia were diagnosed. The course of leukemia passed without any particular complications.

[Electron microscopy morphometry of cells of patients with different immunologic subvariants of acute lymphoblastic leukemia].

By the electron-microscopic morphometry it is determined that the cells of acute lymphoblastic leukemia (ALL) with synonymous immunological phenotype also have the same submicroscopic structure and are characterized by definite morphometric features which distinguish them from lymphoblasts of other subvariants. These results indicate that the electron-microscopic morphometry is one of the criteria for precise identification of leukemic cells. Besides, the similarity of the morphometric features of leukemic cells of the concrete lineage with the synonymous differentiation status confirm their lineage fidelity.