Immunohistochemical analysis of 147 cases of low-grade endometrial stromal sarcoma: refining the immunohistochemical profile of LG-ESS on a large, molecularly confirmed series.

Low-grade endometrial stromal sarcoma (LG-ESS) can present diagnostic challenges, due to its overlapping morphological features with other uterine mesenchymal tumors. Misdiagnosis rates remain significant, and immunohistochemical data for LG-ESS are limited to small series and inconsistent antibody panels. This study aimed to refine the IHC profile of LG-ESS by analyzing a large, molecularly confirmed series of 147 cases using a panel of 24 antibodies, including newer markers like transgelin and smoothelin.

ALTERATIONS IN PLACENTA REDOX-STATUS DURING EXPERIMENTAL MODEL OF HYPOXIA-INDUCED PREECLAMPSIA.

An important pathogenetic link of preeclampsia (PE) is hypoxia of uterine-placental tissues, accompanied by damage of the vascular endothelium and the release of vasoactive mediators, violate vascular tone and microcirculation in the maternal organism and placenta and development of a number of pathological processes in the mother's and fetus body. The aim of the study was to establish metabolic abnormalities of oxidative metabolism of the placenta during experimental model of PE (uterine/placental hypoxia). Studies were performed in pregnant Wistar rats.

MORPHOLOGICAL CHANGES OF RAT PLACENTA IN DIFFERENT PERIODS OF PREGNANCY UNDER MODELED PREECLAMPSIA.

The purpose of the study was to determine the morphological changes of rat placenta in II, III week of pregnancy under modeled preeclampsia. Modeling of preeclampsia was performed in the rats, as follows: lumen of the abdominal aorta below the renal artery was narrowed by the silk tread on the third of its diameter (0.2 mm).

[Alterations in populations of T-lymphocytes in the rats blood during experimental preeclampsia].

Immune tolerance to the fetus is predetermined mainly by HLA-G expression in trophoblasts, varying the ratio of Th1 / Th2, decrease in the content of cytotoxic T lymphocytes and natural killer cells (NK cells) and fusion "tread" of antibodies. The aim of the study was to establish the role of the placental hypoxia in regulation of expression of -lymphocytes populations in the blood of rats at different stages of pregnancy. For the purpose of modeling of PE in pregnant rats, at10-th day of gestation the lumen of the abdominal aorta below the renal artery was narrowed by the silk thread a third of its diameter (0.

[Alterations of immunebalance in the rats blood during experimental preeclampsia].

The aim of the study was to establish a violation of hormonal (progesterone and estradiol) and immune balance (interleukins IL-2, IL-10, TNF-α) in the rats blood at different stages of experimental PE induced by hypoxia placenta. For the purpose of modeling of PE in pregnant rats, at 10-thday of gestation the lumen of the abdominal aorta below the renal artery was narrowed by the silk thread a third of its diameter (0.2 mm).