Publications by authors named "A Shannon"
While the COVID-19 crisis is still ongoing, a new public health threat has emerged with recent outbreaks of monkeypox (mpox) infections in Africa. Mass vaccination is not currently recommended by the World Health Organization (WHO), and antiviral treatments are yet to be specifically approved for mpox, although existing FDA-approved drugs (Tecovirimat, Brincidofovir, and Cidofovir) may be used in severe cases or for immunocompromised patients. A first-line of defense is thus drug repurposing, which was heavily attempted against SARS-CoV-2 - albeit with limited success.
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- Neoadjuvant radiotherapy is crucial for treating locally advanced rectal cancer, and this study compares the quality-of-life outcomes between two techniques: three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).
- A phase II randomized trial involved 94 patients who received chemoradiotherapy and were assigned to either 3DCRT or IMRT; their quality of life was assessed using specific questionnaires throughout the treatment and at a six-month follow-up.
- Although the trial ended early due to the futility of its primary endpoint, the results indicated that while emotional functioning improved, other aspects of quality of life declined; notably, IMRT showed better physical and role functioning during the final week
Management of spontaneous liver hemorrhage in vascular Ehlers Danlos syndrome: A case report.
Int J Surg Case Rep
December 2024
Introduction: Vascular Ehlers Danlos syndrome (vEDS) is a heritable connective tissue disorder characterized by vascular, solid organ, and hollow viscus fragility. Herein we report a patient with vEDS who presented with a large spontaneous subcapsular liver hemorrhage. This case highlights the challenges associated with managing vEDS patients and discusses approaches to optimize their care.
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