A whole-brain functional connectivity model of Alzheimer's disease pathology.

Introduction: Alzheimer's disease (AD) is characterized by the presence of two proteinopathies, amyloid and tau, which have a cascading effect on the functional and structural organization of the brain.

Methods: In this study, we used a supervised machine learning technique to build a model of functional connections that predicts cerebrospinal fluid (CSF) p-tau/Aβ (the PATH-fc model). Resting-state functional magnetic resonance imaging (fMRI) data from 289 older adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) were utilized for this model.

Genome characterization of a simian foamy virus from a human bitten by an African green monkey.

We obtained the near-complete simian foamy virus (SFV) genome from an infected human bitten by an African green monkey ( SFVcae_hu501). The genome is 13,062 nucleotides long with the classical SFV genome structure. Phylogenetically, SFVcae_hu501 clustered closely with SFV from (SFVagm_LK3).

Shifts in the ecological drivers influence the response of tree and soil carbon dynamics in central Himalayan forests.

Understanding and regulating global carbon relies crucially on comprehending the components and services of forest ecosystems. In particular, interactions that govern carbon storage in trees, soil, and microbes, driven by factors like vegetation structure, function, and soil characteristics, remain poorly understood, especially in the central Himalayas. To address this gap, we investigated carbon storage in tree aboveground biomass, root biomass, and soil across different vegetation types.

Avascular necrosis of femoral head - Demographic profile, natural history of asymptomatic hips and native hip survivorship in an indian subcontinent cohort.

Background: Avascular Necrosis of the femoral head is still considered an unsolved orthopedic problem despite significant research and advances in treatment.

Purposes: 1.Describe the demographic pattern2.