Publications by authors named "A Shahsafaei"
Brown adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and humans. Sympathetic stimulation of β-adrenergic receptors in response to cold induces proliferation, differentiation, and UCP1 expression in pre-adipocytes and mature brown adipocytes. Here we show that spleen tyrosine kinase (SYK) is upregulated during brown adipocyte differentiation and activated by β-adrenergic stimulation.
View Article and Find Full Text PDFEZH2, a member of the polycomb protein group, is an important methyltransferase that is overexpressed in various neoplasms. We found that in small cell B-cell lymphomas, EZH2 is expressed in <40% of neoplastic cells, with heterogenous signal intensity. In aggressive B-cell lymphomas, 70-100% of tumor cells were positive for EZH2 expression with high signal intensity, which correlated with a high proliferation rate.
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- Reactive oxygen species (ROS), like hydrogen peroxide (H2O2), play a crucial role in cellular signaling by affecting various proteins, particularly those with critical cysteine residues, leading to a general understanding of ROS signaling as broad and nonspecific.
- New findings indicate that H2O2 signaling behaves more like a formal signal transduction cascade with organized hierarchical events, involving key players such as the mitochondrial respiratory chain, tyrosine-protein kinases Lyn and SYK (Syk).
- This signaling process is consistent across different cell types and organisms, suggesting that the mechanisms involving H2O2 and its effects on Lyn and Syk are essential for regulating a variety of cellular functions, making it an ancient and widely conserved
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator and H3k27-specific histone methyltransferase, is important for transcriptional regulation. EZH2 has been found to be overexpressed in B-cell lymphomas, as well as some T-cell lymphomas. Here we investigated the expression of EZH2 by immunohistochemical staining in a wide range of T-cell neoplasms.
View Article and Find Full Text PDFPlatelet derived growth factor-α (PDGFR-α) is expressed in peripheral T cell lymphoma, not otherwise specified (PTCL, NOS). Imatinib mesylate demonstrated in vitro cytotoxicity against primary PTCL, NOS cells. We initiated a trial of imatinib in 12 patients with relapsed or refractory T-cell non-Hodgkin lymphoma (T-NHL).
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