Cellular composition of the piriform cortex of the rat brain in experimental epilepsy.

The cellular composition of all layers of the anterior, central, and posterior parts of the piriform cortex of the rat brain was studied two weeks and one month after specific electrical stimulation (kindling) of the ventral hippocampus. Stereomicroscopic analysis at both two weeks and one month after kindling showed significant decreases in the numbers of pyramidal cells and interneurons in all layers of all parts of the piriform cortex. At two weeks, the numbers of pyramidal cells and interneurons in the central part of the piriform cortex also decreased in rats in which electrodes were inserted into the ventral hippocampus but without stimulation.

[Cellular composition of the rat piriform cortex in experimental epilepsy].

Cellular composition of all the layers of anterior, central and posterior regions of rat cerebral piriform cortex was studied 2 weeks and 1 month after specific electrical stimulation (kindling) of ventral hippocampus through electrodes implanted one week earlier. According to the data of stereological analysis, following at both time intervals after kindling, all the layers in all the regions of piriform cortex demonstrated the significant decrease in numbers of interneurons and pyramidal cells. Three weeks after electrode implantation into the ventral hippocampus, the number of both pyramidal cells and interneurons was also found to be reduced in the central region of piriform cortex of rats in which stimulation had not been performed.

[The effect of plaferon on disorders in the rabbit brain induced by circulatory hypoxia].

The effect of plaferon on the local cerebral blood flow and brain tissue oxygen tension during transient incomplete ischemia and following recirculation, was studied. The difference revealed between experimental and control data is, probably, due to vasodilatory action of the vasoactive neuropeptides and the effect on the systems of phosphorylation.