Publications by authors named "A Sevcikova"
Immunotherapy with immune checkpoint inhibitors represents a revolutionary approach to the treatment of solid tumors, including malignant melanoma, lung cancer, and gastrointestinal malignancies. Anti-CTLA-4 and anti-PD-1/PDL-1 therapies provide prolonged survival for cancer patients, but their efficacy and safety are highly variable. This review focuses on the crucial role of the gut microbiome in modulating the efficacy and toxicity of immune checkpoint blockade.
View Article and Find Full Text PDFFat mass and obesity-associated (FTO) protein, a key enzyme integral to the dynamic regulation of epitranscriptomic modifications in RNAs, significantly influences crucial RNA lifecycle processes, including splicing, export, decay, and translation. The role of FTO in altering the epitranscriptome manifests across a spectrum of physiological and pathological conditions. This review aims to consolidate current understanding regarding the implications of FTO in health and disease, with a special emphasis on its involvement in obesity and non-communicable diseases associated with obesity, such as diabetes, cardiovascular disease, and cancer.
View Article and Find Full Text PDFArticle Synopsis
- The gut microbiome is crucial for regulating metabolism, immune response, and defending against pathogens, with disruptions linked to cancer development and treatment challenges.
- Tumor-associated microbiota can promote cancer progression through mechanisms like enhanced transition and spread, particularly affecting bones, which are common metastasis sites in certain cancers.
- Research is focused on the relationship between gut microbiome health and bone conditions, exploring dietary interventions and microbiota modulation as potential strategies for improving bone health in cancer patients.
Targeting the gut and tumor microbiome in cancer treatment resistance.
Am J Physiol Cell Physiol
December 2024
Therapy resistance represents a significant challenge in oncology, occurring in various therapeutic approaches. Recently, animal models and an increasing set of clinical trials highlight the crucial impact of the gut and tumor microbiome on treatment response. The intestinal microbiome contributes to cancer initiation, progression, and formation of distant metastasis.
View Article and Find Full Text PDFBackground: Digital technologies have penetrated most workplaces. However, it is unclear how such digital technologies affect the physical health of older workers.
Objective: This scoping review aims to examine and summarize the evidence from scientific literature concerning the impact of digital technology on the physical health of older workers.