[Not Available].

Objectives: This study aims to elucidate the expression patterns of LGALS1 (galectin-1) and LGALS9 (galectin-9) genes in placental tissues of pregnancies affected by preterm prelabor rupture of membranes (PPROM). The overarching goal is to understand the potential roles of these galectins in the pathophysiology of PPROM, particularly in maternal-fetal immune tolerance and placental development.

Material And Methods: Conducted as a prospective, single-center study at the Gynecology and Obstetrics Clinical Hospital in Poznan, Poland, from June 2021 to May 2023, the research involved 25 participants, including 12 with PPROM and 13 healthy controls.

Genetic risk score for gestational weight gain.

Gestational weight gain (GWG) involves health consequences for both mother and offspring. Genetic factors seem to play a role in the GWG trait. For small effect sizes of a single genetic polymorphism (SNP), a genetic risk score (GRS) summarizing risk-associated variation from multiple SNPs can serve as an effective approach to genetic association analysis.

Comprehensive Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Retinopathy of Prematurity: A Study in the Polish Population.

This study was designed to investigate the relationship between variants of matrix metalloproteinases (-1 rs179975, -9 rs17576 and rs17577), their tissue inhibitors (-1 rs4898, -2 rs2277698 and rs55743137) and the development of retinopathy of prematurity (ROP) in infants from the Polish population. A cohort of 100 premature infants (47% female) was enrolled, including 50 ROP cases and 50 no-ROP controls. Patients with ROP were divided into those with spontaneous remission and those requiring treatment.

Common Variants in One-Carbon Metabolism Genes (, , ) and Depression in Gynecologic Cancers.

We investigated the association between methylenetetrahydrofolate reductase (gene 677C>T, rs1801133), 5-methyltetrahydrofolate-homocysteine methyltransferase ( 2756A>G, rs1805087), and methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (gene 1958G>A, rs2236225)-well-studied functional variants involved in one-carbon metabolism-and gynecologic cancer risk, and the interaction between these polymorphisms and depression. A total of 200 gynecologic cancer cases and 240 healthy controls were recruited to participate in this study. Three single-nucleotide variants (SNVs) (rs1801133, rs1805087, rs2236225) were genotyped using the PCR-restriction fragment length polymorphism method.