Publications by authors named "A Sengar"
Background And Aims: In Africa, telemedicine holds great potential to revolutionize surgical care delivery, especially in areas where access to quality treatment is scarce. Data about the use of these services in African countries is, however, limited. To outline the present issues in surgical care delivery, as well as the significant role of telemedicine in advancing surgical care delivery in Africa.
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- Intersectin-1 (Itsn1) is a protein that helps with sending and receiving signals in the brain, especially in a part called the calyx of Held synapse.
- Researchers looked at mice with and without Itsn1 to see how it affected their hearing and signal transmission as they grew up.
- They found Itsn1 is really important for helping the synapse work well, especially in mature mice, as it helps replenish the resources needed for sending signals quickly after they’ve been used.
Kinetic proofreading is used throughout natural systems to enhance the specificity of molecular recognition. At its most basic level, kinetic proofreading uses a supply of chemical fuel to drive a recognition interaction out of equilibrium, allowing a single free-energy difference between correct and incorrect targets to be exploited two or more times. Despite its importance in biology, there has been little effort to incorporate kinetic proofreading into synthetic systems in which molecular recognition is important, such as nucleic acid nanotechnology.
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- MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder linked to genetic duplications of the MECP2 gene and nearby genes like IRAK1.
- Existing mouse models for MDS often only express MECP2, limiting research potential.
- A new CRISPR/Cas9 tandem duplication mouse model called 'Mecp2 Dup' accurately mimics human MDS and shows significant neurobehavioral issues and immune response abnormalities, making it useful for studying the disorder and exploring therapies.
Src dependency of the regulation of LTP by alternative splicing of exon 5.
Philos Trans R Soc Lond B Biol Sci
July 2024
Alternative splicing of exon 5 regulates induction of long-term potentiation (LTP) at Schaffer collateral-CA1 synapses: LTP in mice lacking the GluN1 exon 5-encoded N1 cassette (GluN1a mice) is significantly increased compared with that in mice compulsorily expressing this exon (GluN1b mice). The mechanism underlying this difference is unknown. Here, we report that blocking the non-receptor tyrosine kinase Src prevents induction of LTP in GluN1a mice but not in GluN1b.
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