Publications by authors named "A Semaan"
Background: HPV infection is implicated in approximately half of global penile squamous cell carcinoma (PSCC) cases. Previous studies on HPV DNA and p16INK4a status in PSCC have yielded inconclusive prognostic findings. This meta-analysis aims to elucidate the prognostic role of HPV in PSCC by pooling data on disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS).
View Article and Find Full Text PDFIntroduction: Timely access to emergency obstetric care (EmOC) remains a challenge in sub-Saharan Africa, influenced by poor health care utilization and rapid urbanization. Studies show poor maternal health outcomes in African cities, reflecting weak health systems. Understanding care-seeking pathways is key to improving service delivery and health outcomes.
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- Malignant biphasic tumors of the lungs are uncommon, particularly in children, and this study focuses on unique cases involving pleuropulmonary blastoma Type III and an unclassified thoracic neoplasm.
- The pleuropulmonary blastoma was found to have significant DICER1 mutations and other gene variants, while the unclassified tumor exhibited a specific genetic translocation leading to a YAP1::LEUTX fusion, which has associations with cancer development.
- This research emphasizes the value of whole-genome analysis in identifying the biological characteristics and potential treatment targets for rare tumors.
Article Synopsis
- - The study aimed to determine how common double burden of malnutrition (DBM) and triple burden of malnutrition (TBM) are among mother-child pairs in Malawi, while also examining how these issues vary by location and various factors.
- - Utilizing data from the 2015-2016 Malawi Demographic and Health Survey, researchers found that about 5.5% of mother-child pairs experienced DBM and 3.1% faced TBM, with higher rates occurring in urban areas.
- - The findings revealed that wealthier communities had a threefold increase in DBM, while education improved outcomes, as women with some education showed a 60% lower risk of TBM. This suggests that targeted interventions should
Article Synopsis
- Advanced urothelial cancer displays significant genetic diversity and involves complex interactions between internal and external mutagens, which contributes to its deadly nature.
- The study revealed that APOBEC3-induced mutations occur early during tumor development, while chemotherapy leads to a surge of later mutations, with both processes affecting the structure of extrachromosomal DNA.
- Findings emphasized the role of circular ecDNA in the development of treatment resistance, specifically through CCND1 amplifications, highlighting key mechanisms that can inform future cancer therapies.