Design, synthesis of some novel coumarins and their nanoformulations into lipid-chitosan nanocapsule as unique antimicrobial agents.

Developing and creating novel antibiotics is one of the most important targets in treating infectious diseases. Novel coumarins were synthesized and characterized using different spectroscopic techniques such as Fourier Transform Infrared (FTIR), Nuclear magnetic resonanceH and C and mass spectroscopy (MS). All of the synthesized compounds have been tested for activity and sensitivity against the microbial strains of B.

Synthesis of eco-friendly lipid-magnetite nanocomposite encapsulated Poinciana extract as promising insecticide against Culex pipiens.

Mosquito-borne diseases represent a growing health challenge over time. Nanostructured lipid carriers (NLCs) are the second generation of solid lipid nanoparticles (SLNs), and they continue to attract significant interest as potential diagnostic and therapeutic tools in disease inhibition and insect control. Activated ingredients presented in the Poinciana leaves were extracted and GC-MS data indicated an increased abundance of terpenes, flavonoids, and phenolic substances.

Discovering the inhibition of YAP/TEAD Hippo signaling pathway via new pyrazolone derivatives: synthesis, molecular docking and biological investigations.

Heterocyclic compounds play a crucial role in the drug discovery process and development due to their significant presence and importance. Here, we report a comprehensive analysis of new pyrazolone derivatives, prepared according to a clear-cut, uncomplicated procedure. The pyrazolone derivatives were thoroughly characterized using various methods, such as elemental analysis, NMR, and FT-IR.

Natural benzofuran derivatives as promising scaffold for alleviating Alzheimer symptoms: acetylcholinesterase inhibition, structure activity relationship and studies.

Three isolated natural benzofuran compounds and four semi-synthesized benzofuran derivatives and were evaluated for their acetylcholinesterase inhibition assay. Most of the tested compounds showed moderate activity with IC ranged from 102.4 ± 5.