Publications by authors named "A Seddik"
Clinical Profile and Management of Wolf-Parkinson White Syndrome and Asymptomatic Pre-Excitation Carriers in Africa: A Multicenter Pan African Registry From 17 Countries.
J Cardiovasc Electrophysiol
January 2025
Article Synopsis
- The study explores the management and diagnosis of Wolf-Parkinson White Syndrome (WPW) and asymptomatic pre-excitation in Africa, highlighting a lack of data in the region.
- Conducted in 20 centers across 17 African countries, the research involved 541 participants and focused on symptomatology, treatment approaches, and the impact of local health dynamics on care.
- Results indicated that a vast majority were diagnosed with WPW, with significant regional differences in treatment options and effectiveness, showing that Northern and Southern Africa have more advanced practices compared to other areas.
Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are transmitted through the fecal-oral route. HAV outbreaks and one HEV outbreak have been reported in Egypt. However, the impact of HAV-HEV co-infection is not known.
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- T-DXd is recommended for adult patients with unresectable or metastatic HER2-positive breast cancer who have received previous anti-HER2 treatment, and its cost-effectiveness was evaluated against T-DM1 in Finland.
- A model analyzing lifetime outcomes showed T-DXd yielded more quality-adjusted life years (1.93 QALYs) and life years (2.56 LYs) compared to T-DM1, with incremental costs of €106,800, leading to an incremental cost-effectiveness ratio (ICER) of €55,360 per QALY.
- The study concluded that T-DXd is considered cost-effective under established willingness-to-pay (WTP) thresholds in Finland.
Objectives: Moderate to severe plaque psoriasis is a chronic inflammatory disease. In Germany, guidelines recommend fumaric acid esters (FAEs) as first-line systemic treatment. Despite treatment with FAEs, disease burden remains high in Germany.
View Article and Find Full Text PDFObjectives: Migraine is a highly prevalent neurological disorder. The most characteristic symptom of migraine is moderate to severe recurrent headache along with other neurological symptoms. In this study, we modeled the potential reduction in migraine days and corresponding avoided productivity losses if erenumab was prescribed to the patient population indicated for prophylactic migraine treatment (≥ 4 monthly migraine days [MMDs]) in Germany from 2020 to the end of 2027.
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