Publications by authors named "A Sebastian Schroeder"
Alternative antibiotic selections during the 2022 amoxicillin shortage in the US.
J Pediatric Infect Dis Soc
December 2024
This study of seven pediatric hospitals identified that the amoxicillin shortage in 2022 resulted in a decline in amoxicillin suspension prescribing by 30.8% with increases in use of amoxicillin non-suspension (+7.9) and broad-spectrum antibiotics.
View Article and Find Full Text PDFThe dynamic three-dimensional (3D) organization of the human genome (the "4D Nucleome") is closely linked to genome function. Here, we integrate a wide variety of genomic data generated by the 4D Nucleome Project to provide a detailed view of human 3D genome organization in widely used embryonic stem cells (H1-hESCs) and immortalized fibroblasts (HFFc6). We provide extensive benchmarking of 3D genome mapping assays and integrate these diverse datasets to annotate spatial genomic features across scales.
View Article and Find Full Text PDFStandardising health history and injury surveillance of participants in endurance events: a modified Delphi consensus statement from the AMSSM runner health consortium.
Br J Sports Med
November 2024
Article Synopsis
Article Synopsis
- The integration of translational research with clinical biomarker strategies aims to enhance understanding of disease mechanisms and improve biomarker identification in trials, with high-dimensional flow cytometry (HDFCM) offering a more advanced exploratory approach.
- However, HDFCM presents challenges such as long assay development times, the need for specialized knowledge, and complex data analysis, with no established guidelines for addressing these hurdles in clinical settings.
- The CYTO 2024 workshop sought to reach consensus on the benefits and urgent challenges of HDFCM, summarizing insights to encourage collaboration between the scientific community and regulatory bodies to facilitate HDFCM's implementation in clinical trials.
An enormous diversity of specialized metabolites is produced in the plant kingdom, with each individual plant synthesizing thousands of these compounds. Previous research showed that benzoxazinoids, the most abundant class of specialized metabolites in maize, also function as signaling molecules by regulating the production callose as a defense response. We searched for additional benzoxazinoid-regulated specialized metabolites, characterized them, examined whether they too function in herbivore protection, and determined how Spodoptera frugiperda (fall armyworm), a prominent maize pest, copes with these metabolites.
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