Design of a Digital Twin of the Heart for the Management of Heart Failure Patients.

Heart failure poses a significant global health burden with high prevalence and mortality rates. A promising possibility in this context is the constant monitoring of the patients through telemedicine. The aim of this work is to present a digital twin of a patient at risk of heart failure.

Feature Selection Based on a Genetic Algorithm for Optimizing Weaning Success.

Finding the right time for weaning from ventilator is a difficult clinical decision. Several systems based on machine or deep learning are reported in literature. However, the results of these applications are not completely satisfactory and may be improved.

A High-Throughput Metabolic Microarray Assay Reveals Antibacterial Effects of Black and Red Raspberries and Blackberries against Infection.

infection is commonly treated with a combination of antibiotics and proton pump inhibitors. However, since is becoming increasingly resistant to standard antibiotic regimens, novel treatment strategies are needed. Previous studies have demonstrated that black and red berries may have antibacterial properties.

Non-invasive assessment of muscle fiber conduction velocity during an incremental maximal cycling test.

Muscle fiber conduction velocity (MFCV) gives critical information on neuromuscular control and can be considered a size principle parameter, being suggestive of motor unit recruitment strategies. MFCV has been recently measured during constant-load sub-maximal cycling exercise and was found to correlate positively with percentage of type I myosin heavy chain. The aim of this study was to test the hypothesis that MFCV measured during an incremental cycling test using surface electromyography (sEMG), can be sensitive to the different metabolic requests elicited by the exercise.

Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections.

Objectives: Chronic infections of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients are intractable antibiotic targets because of their biofilm mode of growth. We have investigated the biofilm penetration, mechanism of drug release and in vivo antimicrobial activity of a unique nanoscale liposomal formulation of amikacin designed specifically for nebulization and inhaled delivery.

Methods: Penetration of fluorescently labelled liposomes into sputum or P.