Benefits of Core-Shell Particles over Single-Metal Coatings: Mechanical and Chemical Exposure and Antimicrobial Efficacy.

One of the greatest challenges worldwide is containing the spread of problematic microorganisms. A promising approach is the use of antimicrobial coatings (AMCs). The antimicrobial potential of certain metals, including copper and zinc, has already been verified.

Does Length of Extended Resection Beyond Transition Zone Change Clinical Outcome for Hirschsprung Pull-Through?

Introduction: A proximal resection margin greater than 5 cm from the intra-operative histologically determined transition zone has been deemed necessary to minimize the risk of transition zone pull-through. This extended resection may require the sacrifice of vascular supply and even further bowel resection. The impact of extended proximal resection margin on post-operative complications and functional outcomes is unclear.

The Synthesis and Base-Induced Breakdown of Triaryl 1,4-Oxathiins-An Experimental and DFT Study.

1,4-Oxathiins are valued for a breadth of bioactivities and are known commercial fungicides. This article explores a novel preparation of 2,3,6-trisubstituted 1,4-oxathiin-S,S-dioxides via the reaction of benzyl 1-alkynyl sulfones and aryl aldehydes under basic conditions. A total of 20 examples possessing exclusively a trans arrangement of the 2,3-diaryl substituents are exhibited; the products demonstrate a variation of functional groups on the aryl ring attached to the heterocyclic ring system.

Cope-Type Hydroamination of Vinylboronates.

Aminoboronic acid derivatives can serve as versatile synthetic intermediates and pharmacophores but remain difficult to synthesize. Herein we report a synthesis of the β-aminoboronic acid motif via anti-Markovnikov hydroamination of vinylboronates. This reaction benefits from the activating effect of the boronate substituent and forms novel BON-containing heterocycles, oxazaborolidine zwitterions.

A DFT examination of the role of proximal boron functionalities in the -alkylation of sulfenic acid anions.

Sulfenic acid anions represent an emerging nucleophile for the preparation of sulfoxides. Their S-functionalization chemistry can often be influenced by a nearby group that interacts with the component atoms of the sulfenate through non-bonding interactions. This study uses DFT methods to assess the importance of proximal boron-containing functional groups to direct -alkylation chemistry of selected sulfenate anions.