Publications by authors named "A Schwabe"
Cerebral palsy (CP) is the most common motor disability in children, characterized by diverse clinical manifestations and often uncertain etiology, which has spurred increasing interest in genetic diagnostics. This review synthesizes findings from various studies to enhance understanding of CP's genetic underpinnings. The discussion is structured around five key areas: monogenic causes and copy number variants directly linked to CP, differential genetic disorders including atypical CP and mimics, ambiguous genetic influences, co-occurrence with other neurodevelopmental disorders, and polygenic risk factors.
View Article and Find Full Text PDFBackground The management of adductor spasticity and long-term sequelae for cerebral palsy (CP) patients is complex. Hip displacement is a common consequence of CP, and obturator neurectomy (ON) is a potentially underutilized procedure to address the underlying adductor spasticity. The aim of this study is to describe the operational technique of ON and highlight the potential efficacy of ON in reducing spasticity, as well as pain, hip, and functional outcomes in these patients.
View Article and Find Full Text PDFArticle Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) can vary in aggressiveness, and this study aimed to confirm an automated test for serum chromogranin A (CgA) to help monitor these tumors' progression.
- The study involved 153 GEP-NET patients and assessed tumor progression using imaging alongside changes in CgA levels, with a specific threshold indicating tumor growth.
- Results showed the CgA test had high specificity (93.4%) and negative predictive value (84.3%), suggesting it could be a valuable tool alongside standard imaging methods for tracking GEP-NETs.
Article Synopsis
- * An online survey conducted by the German Society for Public Health Services (DGÖG) gathered input from nearly 500 participants, primarily from local health departments, to prioritize 17 proposed guideline topics across six task areas.
- * All 17 topics were deemed high priority, with a strong emphasis on infection hygiene monitoring, medical expert assessment, and psychosocial emergency care, while additional topics such as health promotion and crisis management were also highlighted for future guideline development.
Objectives: Rheumatoid arthritis (RA) is associated with an increased risk for osteoporosis and osteoporotic fractures. Since the treatment of RA has improved significantly in recent years, we can expect RA-associated osteoporosis to decrease with good disease control. Therefore, we conducted a retrospective study to investigate whether the frequency of osteoporosis and osteoporotic fractures has changed during 24 years in RA.
View Article and Find Full Text PDF