Publications by authors named "A Schroeter"
Aseptic filling of biopharmaceutical products requires a grade A cleanroom environment, preferably ensured by isolators in grade C surroundings. Isolators are decontaminated before the start of filling processes using vaporized hydrogen peroxide (VHP) and filling starts at pre-defined residual VHP levels (e.g.
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- The study investigates the impact of older donor organs on younger recipients in organ transplantation, hypothesizing that aging donor organs can induce cellular senescence in younger mice.
- Results showed that young and middle-aged mice receiving older organs exhibited increased senescent cells in various tissues and experienced diminished physical performance and cognitive abilities within 30 days.
- Treatment with senolytics, which target and eliminate senescent cells, was found to reduce harmful effects of the old organs and improve physical performance in younger recipients, suggesting a potential strategy for enhancing transplant outcomes.
Article Synopsis
- Machine perfusion (EVMP) is a new method used for preserving solid organs, particularly in organ transplants, that improves upon traditional cold preservation by allowing for better monitoring and reducing damage during preservation.
- This technique has broadened the donor pool by including organs from expanded criteria donors, such as those from circulatory death cases, and shows potential for treating and modifying diseased organs.
- The review discusses key differences in EVMP applications for various organs (kidney, liver, lung, heart) and explores both the benefits and limitations of this technique, highlighting the need for interdisciplinary approaches in its development.
Biological sex affects immunity broadly, with recognized effects on the incidence and severity of autoimmune diseases, infections, and malignancies. Consequences of sex on alloimmunity and outcomes in solid organ transplantation are less well defined. Clinical studies have shown that donor and recipient sex independently impact transplant outcomes, which are further modified by aging.
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- - Vascularized composite allotransplantation (VCA) is a new surgical method that helps treat severe injuries, such as losing limbs or facial injuries, by transplanting various tissue types like skin, bone, and muscle.
- - The body's immune system often rejects VCA grafts, especially those with skin, due to their strong antigenicity, which challenges the balance between accepting and rejecting the transplant.
- - Recent research is uncovering the immune cells involved in graft rejection, aiming to develop targeted therapies that could improve the management of VCA transplant patients and potentially reduce the need for lifelong immunosuppression.