Publications by authors named "A Schoubben"
Ochratoxin A (OTA) is a mycotoxin produced by and various species, which are known for contaminating agricultural products and posing significant health risks, which include immunotoxicity. This study aims to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with a carotenoid-enriched extract from pumpkin peel ( L.) in mitigating the toxic effects of OTA.
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- - Nanomedicine enhances disease treatment by enabling targeted therapies, controlled drug release, and personalized drug delivery systems, leading to more effective treatments with fewer side effects.
- - The integration of stimuli-responsive nanoparticles and electrochemical sensors allows for precise targeting of affected tissues, particularly in conditions like cancer and genetic diseases.
- - Although still in early stages, the combination of advanced technology with innovative drug delivery systems shows potential as a viable alternative to current treatments, with personalized approaches improving patient outcomes.
Biological membrane-engineered lipid nanoparticles (LNP) have shown enormous potential as vehicles for drug delivery due to their outstanding biomimetic properties. To make these nanoparticles more adaptable to complex biological systems, several methods and cellular sources have been adopted to introduce biomembrane-derived moieties onto LNP and provide the latter with more functions while preserving their intrinsic nature. In this review, we focus on LNP decoration with specific regard to mRNA therapeutics and vaccines.
View Article and Find Full Text PDFTomato by-products represent a good source of phytochemical compounds with health properties, such as the steroidal glycoalkaloid α-tomatine (α-TM) and its aglycone tomatidine (TD). Both molecules have numerous beneficial properties, such as potential anticancer activity. Unfortunately, their therapeutic application is limited due to stability and bioavailability issues.
View Article and Find Full Text PDFBiodegradable metal alloys may be successfully used to support bone repair, avoiding second surgery commonly needed when inert metal alloys are used. Combining a biodegradable metal alloy with a suitable pain relief agent could improve patient quality of life. AZ31 alloy was coated using a poly(lactic-co-glycolic) acid (PLGA) polymer loaded with ketorolac tromethamine using the solvent casting method.
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