Validity and feasibility of four standardized aerobic fitness tests in patients with depression: A cross-sectional study.

The objective of this study was to examine the validity and feasibility of four standardized aerobic fitness tests to either measure V˙ Opeak or to estimate V˙ Omax (e V˙ Omax) in patients with major depression disorder (MDD). To this end, all subjects (n = 43) performed one maximal cardiopulmonary exercise test with gas exchange measurement (CPET) on a bicycle ergometer. Additionally, three submaximal tests (Åstrand-Rhyming bicycle ergometer test [ART], Physical work capacity test [PWC], and 6-min walk test [6MWT]) were performed within two weeks in counterbalanced order.

Selective COX-2 Inhibitors as Neuroprotective Agents in Traumatic Brain Injury.

Traumatic brain injury (TBI) is a significant contributor to mortality and morbidity in people, both young and old. There are currently no approved therapeutic interventions for TBI. Following TBI, cyclooxygenase (COX) enzymes generate prostaglandins and reactive oxygen species that perpetuate inflammation, with COX-1 and COX-2 isoforms providing differing responses.

The moderating effect of social support on the effectiveness of a web-based, computer-tailored physical activity intervention for older adults.

This study aimed to assess the moderating effect of social support on the effectiveness of a web-based, computer-tailored physical activity intervention for older adults. In the trial, 243 inactive adults aged 65+ years were randomised into: (1) tailoring + Fitbit ( = 78), (2) tailoring-only ( = 96) or (3) control ( = 69). For the current study, participants were categorised as having higher ( = 146) or lower ( = 97) social support based on the Duke Social Support Index (DSSI_10).

Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model.

Repetitive mild traumatic brain injuries (rmTBI) may contribute to the development of neurodegenerative diseases through secondary injury pathways. Acetyl-L-carnitine (ALC) shows neuroprotection through anti-inflammatory effects and via regulation of neuronal synaptic plasticity by counteracting post-trauma excitotoxicity. This study aimed to investigate mechanisms implicated in the etiology of neurodegeneration in rmTBI mice treated with ALC.

Engagement, acceptability, usability and satisfaction with Active for Life, a computer-tailored web-based physical activity intervention using Fitbits in older adults.

Background: Preliminary evidence suggests that web-based physical activity interventions with tailored advice and Fitbit integration are effective and may be well suited to older adults. Therefore, this study aimed to examine the engagement, acceptability, usability, and satisfaction with 'Active for Life,' a web-based physical activity intervention providing computer-tailored physical activity advice to older adults.

Methods: Inactive older adults (n = 243) were randomly assigned into 3 groups: 1) tailoring + Fitbit, 2) tailoring only, or 3) a wait-list control.