Publications by authors named "A SchloSSbauer"
Article Synopsis
- The "flipped classroom" approach allows students to prepare learning materials on their own before attending class, promoting a consistent knowledge base and enhancing practical exercises.
- A new teaching module was implemented in the ophthalmology curriculum at the University of Münster, combining efforts between the ophthalmology department and the Institute for Education and Study Affairs (IfAS), with subsequent evaluations conducted through an online survey.
- The results indicated that students taught through the flipped classroom model had a better overall assessment compared to traditional teaching methods, suggesting improved learning outcomes; however, further research is needed to explore the long-term retention of knowledge.
Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.
View Article and Find Full Text PDFRedox-driven intracellular disulfide-cleavage is a promising strategy to achieve stimuli-responsive and controlled drug release. We synthesized colloidal mesoporous silica (CMS) nanoparticles with ATTO633-labeled cysteine linked to the inner particle core via disulfide-bridges and characterized their cysteine release behavior after internalization into HuH7 cells by high-resolution fluorescence microscopy. Our study revealed that endosomal escape is a bottleneck for disulfide-linkage based drug release.
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