Publications by authors named "A Schild"
Background: Value-based healthcare (VBHC) is a novel concept derived from economic research which is recently implemented in various medical departments and facilities. Additionally to an improvement of patient care, it postulates a reduction of expenses by providing patients with what they really need. Value in this context is defined as outcomes achieved for patients relative to the required costs.
View Article and Find Full Text PDFThe adenosine A1 receptor (AR) is a promising target for pain treatment. However, the development of therapeutic agonists is hampered by adverse effects, mainly including sedation, bradycardia, hypotension, or respiratory depression. Recently discovered molecules able to overcome this impediment are the positive allosteric modulator MIPS521 and the A1R-selective agonist BnOCPA, which are both potent and powerful analgesics with fewer side effects.
View Article and Find Full Text PDFIntroduction: Understanding the impact of biomarker-based dementia risk estimation in people with mild cognitive impairment (MCI) and their care partners is critical for patient care.
Methods: MCI patients and study partners were counseled on Alzheimer's disease (AD) biomarker and dementia risk was disclosed. Data on mood, quality of life (QoL), and satisfaction with life (SwL) were obtained 1 week and 3 months after disclosure.
Article Synopsis
- * Using CMGC inhibitors to affect RBM39 results in decreased protein levels and reduced ALL growth, especially in difficult-to-treat cases.
- * The research shows that altering the interaction between RNA polymerase II and splicing factors due to kinase inhibition can promote the inclusion of the poison exon, revealing new avenues for effective treatment against relapsed B-ALL.
Objective: This study aimed to describe menopause and treatment experiences of women with vasomotor symptoms due to menopause in the United States.
Methods: A cross-sectional survey was administered to women 40-65 years of age recruited from PatientsLikeMe, a dedicated online platform for patients.
Results: A total of 196 women (mean age 55.