Publications by authors named "A Schibler"
Renal chloride metabolism is currently poorly understood but may serve as both a diagnostic and a treatment approach for acute kidney injury. We investigated whether plasma chloride, ammonia and glutamine as well as urinary chloride, ammonium and glutamine concentrations may serve as markers for acute kidney injury in paediatric patients. We conducted a prospective observational trial in a tertiary care paediatric intensive care unit.
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- - The study explored the effectiveness of nasal high-flow oxygen versus standard oxygen therapy during tubeless upper airway surgeries in children, to see if it could reduce the need for rescue oxygen interventions.
- - Conducted in five Australian hospitals, the trial involved 581 procedures with children aged 0-16 years, and aimed to determine whether high-flow oxygen could maintain uninterrupted surgical anesthesia.
- - Results from the trial, which included ten secondary outcomes like hypoxia events and was registered under a clinical trials registry, indicated a comprehensive assessment of safety and effectiveness.
Article Synopsis
- The study investigates the clinical use of nasal high-flow therapy for infants with bronchiolitis in Australian hospitals, focusing on the choice of initial oxygen therapy and the severity of the disease prior to treatment.
- Among 235 infants, those receiving high-flow therapy showed more severe respiratory symptoms and a longer hospital stay (0.6 days), with a higher rate of transfers to intensive care compared to those on standard oxygen therapy.
- The findings suggest that infants with greater disease severity are more likely to be treated with high-flow therapy, leading to more escalated care despite similar severity levels in both treatment groups.
Article Synopsis
- A pilot trial compared nasal high-flow (NHF) therapy with standard oxygen therapy (SOT) in children with acute respiratory failure to evaluate therapy escalation and hospital stay length.
- The study used a decision tree model to analyze cost-effectiveness from a healthcare perspective, focusing on incremental costs per length of stay avoided across different patient types.
- Results indicated NHF may be cost-effective for non-obstructive patients needing escalated care, but generally, it is unlikely to be more cost-effective than SOT for most other groups.