Publications by authors named "A Schiavi"

Turbomachinery engines face significant failure risks due to the combination of thermal loads and high-amplitude vibrations in turbine and compressor blades. Accurate stress distribution measurements are critical for enhancing the performance and safety of these systems. Blade tip timing (BTT) has emerged as an advanced alternative to traditional measurement methods, capturing blade dynamics by detecting deviations in blade tip arrival times through sensors mounted on the stator casing.

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The "architectural suitability" of scaffolds for bone tissue engineering is commonly evaluated by assessing the pore volume and the mean pore size (or pore size distribution, if possible) and comparing these values with the reference ranges of human cancellous bone. However, these two parameters cannot precisely describe the complex architecture of bone scaffolds and just provide a preliminary comparative criterion. Permeability is suggested as a more comprehensive and significant parameter to characterize scaffold architecture and mass transport capability, being also related to bone in-growth and, thus, functional properties.

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Purpose: Carbon ion therapy treatments can be monitored non-invasively with in-beam Positron Emission Tomography (PET). At CNAO the INSIDE in-beam PET scanner has been used in a clinical trial (NCT03662373) to monitor cancer treatments with proton and carbon therapy. In this work we present the analysis results of carbon therapy data, acquired during the first phase of the clinical trial, analyzing data of nine patients treated at CNAO for various malignant tumors in the head-and-neck region.

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Sensors based on MEMS technology, in particular Inertial Measurement Units (IMUs), when installed on vehicles, provide a real-time full estimation of vehicles' state vector (e.g., position, velocity, yaw angle, angular rate, acceleration), which is required for the planning and control of cars' trajectories, as well as managing the in-car local navigation and positioning tasks.

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Article Synopsis
  • Mitochondria and lysosomes are interdependent organelles that affect each other's functions, where defects in one lead to issues in the other.
  • Recent research using RNA sequencing has revealed that mitochondrial defects lead to downregulation of cholesterol synthesis pathways, while lysosomal defects lead to their upregulation.
  • The study also identified the role of the transcription factor SREBF1 in this regulation and demonstrated that balancing calcium levels in lysosomes can alleviate some developmental issues linked to mitochondrial dysfunction in a model organism, C. elegans.
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