A phase II trial of autologous transplantation of bone marrow stem cells for critical limb ischemia: results of the Naples and Pietra Ligure Evaluation of Stem Cells study.

Critical limb ischemia (CLI) is a vascular disease affecting lower limbs, which is going to become a demanding challenge because of the aging of the population. Despite advances in endovascular therapies, CLI is associated with high morbidity and mortality. Patients without direct revascularization options have the worst outcomes.

Medical management of cutaneous sulfur mustard injuries.

Background: Sulfur mustard (2,2'-dichlorodiethyl sulfide; HD) is a potent vesicating chemical warfare agent that poses a continuing threat to both military and civilian populations. Significant cutaneous HD injuries can take several months to heal, necessitate lengthy hospitalizations, and result in long-term complications. There are currently no standardized or optimized methods of casualty management.

Cardiomyopathy in captive owl monkeys (Aotus nancymae).

Dilated cardiomyopathy (DCM) was identified histopathologically in a colony of owl monkeys (Aotus nancymae) over a 15-year period. We characterized the incidence of cardiac disease echocardiographically in the colony over a 14-month period. Of 77 monkeys, 21 had systolic myocardial failure, and postmortem examination confirmed the antemortem diagnosis of DCM in eight animals.

Variable susceptibility of the owl monkey (Aotus nancymae) to four serotypes of dengue virus.

The goal of this study was to determine, for each of four dengue serotypes, whether owl monkeys (Aotus nancymae) become viremic and develop antibody responses in patterns similar to those seen in humans and whether any behavioral parameters are reliably associated with immunologic responses. A secondary goal was to investigate effects of chronic blood sampling on hematologic parameters in this genus. We inoculated 20 owl monkeys with 2 x 10(4) plaque-forming units of one of four dengue serotypes.

Validation of flow convergence region method in the assessment of carotid artery stenoses during color-flow duplex studies.

Purpose: The flow convergence region (FCR) method (also known as the proximal isovelocity surface area method) is currently used in echocardiography to evaluate the flow through cardiac valves and septal defects. The FCR method is based on the characteristic alterations in flow dynamics that occur proximal to a stenotic orifice. Blood converges uniformly and radially towards an orifice that is small relative to the section of the vessel and forms concentric isovelocity hemispheric shells where velocity progressively increases and flow remains laminar.