Publications by authors named "A Scherpereel"
Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothesised that endocrine rather than paracrine pathways mediate the therapeutic response. We thus studied the effect of eosinophil-associated factors on response to chemotherapy in mesothelioma.
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- * A total of 2,515 patients were examined, primarily with lung and renal cancer, revealing a one-year survival rate of 84.3% and low mortality and morbidity rates post-surgery.
- * Findings indicate that while adrenalectomy is increasingly performed minimally invasively, factors like extra-adrenal metastases and incomplete surgery are linked to poorer survival outcomes, highlighting a need for future research on patient selection for this procedure.
Background: Mesothelioma is a rare and aggressive malignant neoplasm arising from mesothelial cells, which occasionally manifests recurrent fusions. EWSR1/FUS-CREB, YY1, MAP3K8, NR4A3, and ALK-rearranged proliferations have been reported in limited series with no clear histological or clinical correlations, limiting clinicians' ability to assess prognosis and integrate these new entities into therapeutic decisions. The aim of this study was to better characterize these rearranged proliferations histologically, molecularly, and clinically.
View Article and Find Full Text PDFBackground: First-line standard-of-care for unresectable, pleural mesothelioma (PM) changed with the phase 3 CheckMate 743 study results, showing that nivolumab plus ipilimumab (Nivo + Ipi) significantly extended overall survival (OS) versus platinum + pemetrexed chemotherapy for PM (median OS 18.1 versus 14.1 months; hazard ratio: 0.
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- The gut microbiota plays a significant role in how cancer patients respond to immune checkpoint inhibitors (ICIs), but there’s no clear definition of harmful dysbiosis.* -
- Researchers analyzed fecal samples from 245 non-small cell lung cancer (NSCLC) patients, identifying specific bacterial species groups associated with either resistance or response to ICIs, resulting in the creation of a topological score (TOPOSCORE).* -
- This TOPOSCORE was further validated in additional patient cohorts and transformed into a 21-bacterial probe set for qPCR scoring, suggesting it could serve as a dynamic tool for diagnosing intestinal dysbiosis and tailoring microbiota-focused treatments.*