Women younger than 50 years with endometrial cancer.

Purpose Of Investigation: The purpose of the study was to evaluate if known risk factors for endometrial cancer in menopausal women are also related to endometrial cancer in younger ages.

Methods: Eighty-one patients with a mean age of 46.3 years diagnosed with endometrial cancer (EC) (histologically confirmed) from January of 1992 to December of 2004 were included in the study.

Effects of chronic glucocorticoid excess in man on insulin binding to circulating cells: differences between endogenous and exogenous hypercorticism.

We measured [125I]insulin binding to circulating monocytes or erythrocytes from 16 patients with chronic glucocorticoid excess, 9 chronically treated with prednisone and 7 with adrenocortical hyperfunction. With monocytes, [125I]insulin binding was iincreased in all patients. Analysis of binding data indicated that increased binding in patients treated with prednisone was due to an ncrease in receptor concentration, whereas in patients with adrenocortical hyperfunction, it was due to an increase in receptor affinity.