Boroxazolidones: Synthesis, In Silico and In Vitro Evaluation as ACE/AChE Dual Inhibitors, and In Vivo Testing of Antihypertensive Activity.

Background: Systemic arterial hypertension is a serious chronic health problem caused by multiple factors. It is a major risk factor for Cardiovascular Diseases (CVDs), including heart failure, coronary heart disease, and myocardial infarction. Hypertension can be effectively treated with inhibitors of the Angiotensin Converting Enzyme (ACE), such as captopril, enalapril, and lisinopril.

Experimental study of influence of composition on radiopacity of fiber post materials.

This experimental study aims to evaluate the radiopacity of various fiber post materials and to determine the effects of material composition as analyzed by energy-dispersive X-ray spectrophotometry (EDS; EDAX Team Software; EDAX, Inc., Mahwah, NJ) on radiopacity. Five specimens of seven fiber post materials with 2-mm thickness were prepared and digital radiographs were taken with an aluminum stepwedge (SW) and 2-mm-thick tooth slice.

Venous coupler use for free-flap breast reconstructions: specific analyses of TMG and DIEP flaps.

Purpose: The purpose of this report was to present the results of comparisons of anastomotic data and flap complications in the use of venous coupler in breast reconstruction with the transverse musculocutaneous gracilis (TMG) flap and the deep inferior epigastric perforator (DIEP) flap.

Methods: Over a three-year period, 95 patients suffering from breast cancer were treated with mastectomy and breast reconstruction using free flaps. We performed 121 mechanical venous anastomoses for 105 flap procedures (80 DIEP and 25 TMG).

Measurement of cardiac output with non-invasive Aesculon impedance versus thermodilution.

Background: This study compared the non-invasive thoracic electrical bioimpedance Aesculon technique (TEB(Aesculon) ) with thermodilution (TD) to evaluate whether TEB(Aesculon) may offer a reliable means for estimating cardiac output (CO) in humans.

Material And Method: Cardiac output was measured with TD and TEB(Aesculon) in 33 patients, with a mean age ± SEM of 59 ± 2·7 years, that underwent right heart catheterization for clinical investigation of pulmonary hypertension or severe heart failure. Four to five CO measurements were performed with each technique simultaneously in 33 patients at rest, 11 during exercise and seven during NO inhalation.

Growth hormones reverse desensitization of P2Y(2) receptors in rat mesangial cells.

Rat glomerular mesangial cells (GMC) express P2Y(2) purinoceptors and respond to nucleotide stimuli with a transient increase in the cytosolic Ca(2+) concentration and the receptors desensitize upon repeated stimulation with nucleotide. We demonstrate that there is a cross-talk from the signaling of tyrosine kinase to P2Y(2) receptors. For most cells repeated applications of ATP completely abolished the response, as did activation of PKC with 500 nM PMA.