Publications by authors named "A Sattler"
Article Synopsis
- Metastatic progression in cancers worsens survival rates and complicates treatment, prompting the development of an mRNA therapy aimed at inhibiting metastasis by targeting activin A, a key factor in metastasis and cachexia.
- This therapy uses follistatin mRNA lipid nanoparticles to effectively reduce activin A levels, resulting in lowered tumor burden and less metastatic spread in a mouse model of head and neck cancer.
- Treated mice showed less metastatic occurrence, preserved muscle and fat tissue, and a good safety profile, suggesting the therapy could be widely applicable across different cancers due to the common overexpression of activin A.
Hypothalamic inflammation often coincides with cancer and cachexia-anorexia. Prior work established the significance of tumor-derived inflammatory factors in triggering hypothalamic inflammation, yet the precise mechanisms remained elusive. Here, we demonstrate that prostaglandin E2 (PGE2), produced in the tumor via cyclooxygenase-2 (COX-2), plays a pivotal role in this context.
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- The study focuses on pancreatic ductal adenocarcinomas (PDAC) and highlights the need for early detection, suggesting biomarkers like GDF15 and LCN2 could be valuable in this context.
- Analysis of circulating levels of GDF15 and LCN2 in PDAC patients showed higher concentrations compared to healthy controls and those with benign diseases, with GDF15 linked to disease progression and mortality.
- Findings indicate that GDF15 is a promising biomarker for early detection and prognosis of PDAC, while LCN2 could enhance diagnostic accuracy when combined with GDF15 or CA19-9.
mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for treating various diseases. While mRNA vaccines anticipate immunogenicity, the associated reactogenicity of mRNA-loaded LNPs poses significant challenges, especially in protein replacement therapies requiring multiple administrations, leading to adverse effects and suboptimal therapeutic outcomes. Historically, research has primarily focused on the reactogenicity of mRNA cargo, leaving the role of LNPs understudied in this context.
View Article and Find Full Text PDFThe purpose of the study was to determine the prevalence of sudden cardiac arrest (SCA) risk factors in high school (HS) athletes. Thirty-three male soccer players from a public HS in the southeastern United States (ages 14-17) self-reported survey data. Participants reported demographic, lifestyle, heart health, COVID-19 history, and symptoms indicative of SCA risk.
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