Publications by authors named "A Sarachakov"
Background: Treatments after anti-PD-1 therapy for patients with recurrent, metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) are limited. Blocking phosphatidylinositol 3-kinase (PI3K) signaling may lead to tumor immunomodulation and enhanced taxane sensitivity. This phase 2 trial evaluated dual, selective PI3Kδ/γ inhibition with docetaxel in patients with anti-PD-1 refractory R/M HNSCC.
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- Follicular lymphoma (FL) is an incurable cancer that arises from B cells in the germinal center and is characterized by genetic changes and a restructured lymphoid microenvironment to evade the immune system.
- The interactions between tumor B cells and their surrounding microenvironment are believed to influence the varying clinical outcomes in FL patients, yet current clinical tools fail to accurately predict these behaviors.
- In a study involving FL patients in a clinical trial, researchers identified specific tumor characteristics and microenvironmental patterns, such as stromal desmoplasia, that are linked to early relapse, indicating potential markers for high-risk patients.
The spatial anatomy of hematopoiesis in the bone marrow (BM) has been extensively studied in mice and other preclinical models, but technical challenges have precluded a commensurate exploration in humans. Institutional pathology archives contain thousands of paraffinized BM core biopsy tissue specimens, providing a rich resource for studying the intact human BM topography in a variety of physiologic states. Thus, we developed an end-to-end pipeline involving multiparameter whole tissue staining, in situ imaging at single-cell resolution, and artificial intelligence-based digital whole slide image analysis and then applied it to a cohort of disease-free samples to survey alterations in the hematopoietic topography associated with aging.
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