Publications by authors named "A Sapirstein"

Purpose: Cancers are a growing cause of mortality especially in low- and middle-income countries in Africa. Rwanda is no exception. Two cancer centers currently provide care to the public, but there are both political and human interest in expanding access to tertiary cancer care.

View Article and Find Full Text PDF
Article Synopsis
  • The study explores how natural and induced somatic mutations in the genome can serve as "lineage barcodes" to track cellular relationships and their development over time.
  • The authors introduce a method called quantitative fate mapping, which reconstructs the hierarchy and dynamics of progenitor cell states during development using these lineage barcodes.
  • They present a tool named Phylotime for creating time-scaled phylogenies and validate its effectiveness through experiments, establishing guidelines for analyzing the necessary number of cells for accurate fate mapping.
View Article and Find Full Text PDF

Objective: To compare the insulin infusion management of critically ill patients by nurses using either a common standard (ie, human completion of insulin infusion protocol steps) or smart agent (SA) system that integrates the electronic health record and infusion pump and automates insulin dose selection.

Design: A within subjects design where participants completed 12 simulation scenarios, in 4 blocks of 3 scenarios each. Each block was performed with either the manual standard or the SA system.

View Article and Find Full Text PDF

The coronavirus disease 2019 pandemic may require rationing of various medical resources if demand exceeds supply. Theoretical frameworks for resource allocation have provided much needed ethical guidance, but hospitals still need to address objective practicalities and legal vetting to operationalize scarce resource allocation schemata. To develop operational scarce resource allocation processes for public health catastrophes, including the coronavirus disease 2019 pandemic, five health systems in Maryland formed a consortium-with diverse expertise and representation-representing more than half of all hospitals in the state.

View Article and Find Full Text PDF