Publications by authors named "A Santika"

Nitrogen and oxygen-based functionalized carbon dot (CDs) surfaces have attracted significant attention due to their ability to tailor the optical and electronic properties of CDs. However, the complex synthesis process and structure of the functionalized CDs hinder an in-depth understanding of their mechanism, limiting their potential applications. Herein, we report CDs functionalized with amino and carbonyl functional groups and reveal the mechanism of interaction between the amino and carbonyl groups and the CDs' optical and electronic properties.

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Koi herpesvirus disease (KHVD) is an emerging disease that causes mass mortality in koi and common carp, L. Its causative agent is Cyprinid herpesvirus 3 (CyHV-3), also known as koi herpesvirus (KHV). Although data on the pathogenesis of this deadly virus is relatively abundant in the literature, still little is known about its genomic diversity and about the molecular mechanisms that lead to such a high virulence.

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Cyprinid herpesvirus 3 (CyHV-3), the causative agent of koi herpesvirus disease, is a major threat for carp populations in many countries worldwide, including Indonesia. It has been shown that many genotypes circulate worldwide, all highly related to one of the two known lineages U/I and J. In this study, we evaluated the spatial and temporal distribution of CyHV-3 strains in a small enzootic area, the lake of Cirata (West Java, Indonesia).

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Article Synopsis
  • - Cyprinid herpesvirus-3 (CyHV-3), also known as koi herpesvirus (KHV), causes significant death rates in common and koi carp globally, impacting aquaculture.
  • - Analysis of the genomes of three CyHV-3 isolates showed over 99% DNA sequence similarity, with variations largely in short tandem repeats (VNTRs), leading to the selection of eight loci for genotyping using multiple locus VNTR analysis (MLVA).
  • - The study found that while CyHV-3 strains from sequential infections had identical profiles, in vitro passaged strains showed mutations, indicating slow genetic evolution; further analysis of samples from multiple countries revealed two main genetic clusters, useful for assessing genetic diversity and aiding future epidemi
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