Publications by authors named "A Santaolalla"
Article Synopsis
- The study reviews the role of glycosylation in human IgE (Immunoglobulin E) and how it affects its structure, function, and relation to diseases, especially allergies.
- It emphasizes that despite inconsistent findings from various studies, there is evidence of different glycosylation patterns in allergic vs. healthy individuals and their functional implications in allergic reactions.
- The review suggests that certain glycosylation changes could lead to potential therapeutic targets and underscores the need for improved research methods to further investigate these effects.
Background: Rapid diagnostic clinics (RDCs) provide a streamlined holistic pathway for patients presenting with non-site specific (NSS) symptoms concerning of malignancy. The current study aimed to: 1) assess the prevalence of anxiety and depression, and 2) identify a combination of patient characteristics and symptoms associated with severe anxiety and depression at Guy's and St Thomas' Foundation Trust (GSTT) RDC in Southeast London. Additionally, we compared standard statistical methods with machine learning algorithms for predicting severe anxiety and depression.
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- Advancements in understanding myelodysplastic neoplasms (MDS) have revealed important cellular and molecular factors that influence disease progression, highlighting the significance of immune dysregulation in the bone marrow during MDS evolution.
- Despite these advancements, immunotherapy for MDS has lagged due to a lack of effective immune classifications for patient stratification and no widely accepted immune panels for clinical use.
- To address these challenges, the i4MDS consortium proposes standardized immune monitoring approaches, including flow cytometry panels and cytokine assays, aiming to improve patient stratification and develop predictive markers for treatment response in MDS.