Publications by authors named "A Santander"
Article Synopsis
- Bacterial toxins, specifically enterotoxigenic toxins like LT, can affect heart function by binding to receptors on heart cells (cardiomyocytes), which may lead to conditions like cardiomyopathy and sudden cardiac death (SIDS).
- LT disrupts calcium homeostasis in heart cells, impacting their electrical activity and leading to significant alterations in heart performance, such as increased heart rate variability and changes in action potentials.
- The findings suggest that the B subunit of the LT toxin plays an active role in heart dysfunction and points to a possible link between enterotoxigenic bacteria and instances of sudden cardiac death, emphasizing a need for further understanding of this connection.
Nutrigenomics of inward rectifier potassium channels.
Biochim Biophys Acta Mol Basis Dis
October 2023
Inwardly rectifying potassium (Kir) channels play a key role in maintaining the resting membrane potential and supporting potassium homeostasis. There are many variants of Kir channels, which are usually tetramers in which the main subunit has two trans-membrane helices attached to two N- and C-terminal cytoplasmic tails with a pore-forming loop in between that contains the selectivity filter. These channels have domains that are strongly modulated by molecules present in nutrients found in different diets, such as phosphoinositols, polyamines and Mg.
View Article and Find Full Text PDFIntestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome.
Cell Mol Gastroenterol Hepatol
September 2023
Background & Aims: Metabolic syndrome (MetS) is characterized by obesity, glucose intolerance, and hepatic steatosis. Alterations in the gut microbiome play important roles in the development of MetS. However, the mechanisms by which this occurs are poorly understood.
View Article and Find Full Text PDFA methodological proposal of a scale for human perception assessment of acoustic environment (acoustic comfort) in urban public spaces is presented: Acoustic Comfort Assessment Scale (ACAS 12). This paper shows the process of constructing this scale and its psychometric properties and validation. The approach is based on the soundscape conceptualisation collected in ISO 12913-1:2014 (Acoustics-Soundscape: Definition and conceptual framework).
View Article and Find Full Text PDFBackground And Aims: Lamina propria phagocytes are key mediators of inflammatory bowel disease (IBD). We aimed to understand the transcriptomic and functional differences in these cells based on location, disease type, inflammation state, and medication use in patients with IBD.
Methods: Phagocytic immune cells in the lamina propria, as defined by the marker CD11b, were isolated from 54 unique patients (n = 111 gut mucosal biopsies).