Publications by authors named "A Sanpavat"
Article Synopsis
- Guidelines suggest that patients with high-risk gastric intestinal metaplasia should have endoscopic surveillance for gastric cancer every three years.
- This study explored the effectiveness of radiofrequency ablation (RFA) in completely eliminating high-risk gastric intestinal metaplasia.
- Results showed that RFA led to a significantly higher complete resolution rate of GIM lesions compared to a group receiving only observation, particularly in those with incomplete GIM.
Article Synopsis
- Genetic analysis of eight Thai children diagnosed with hepatic glycogen storage diseases (GSD) revealed various subtypes through whole-exome sequencing, with common symptoms including hepatomegaly and hypoglycemia.
- Treatments primarily involved cornstarch supplementation and dietary adjustments, leading to improved health outcomes over a median follow-up of nearly 10 years.
- The study emphasizes the importance of molecular analysis for accurate diagnosis and tailored treatment plans for better long-term management of GSD in affected patients.
Development of a diagnostic support system for the fibrosis of nonalcoholic fatty liver disease using artificial intelligence and deep learning.
Kaohsiung J Med Sci
August 2024
Liver fibrosis is a pathological condition characterized by the abnormal proliferation of liver tissue, subsequently able to progress to cirrhosis or possibly hepatocellular carcinoma. The development of artificial intelligence and deep learning have begun to play a significant role in fibrosis detection. This study aimed to develop SMART AI-PATHO, a fully automated assessment method combining quantification of histopathological architectural features, to analyze steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD) core biopsies and employ Metavir fibrosis staging as standard references and fat assessment grading measurement for comparison with the pathologist interpretations.
View Article and Find Full Text PDFSeveral diseases originate from bile duct pathology. Despite studies on these diseases, certain etiologies of some of them still cannot be concluded. The most common disease of the bile duct in newborns is biliary atresia, whose prognosis varies according to the age of surgical correction.
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- Oxidative stress plays a crucial role in cancer development, particularly in hepatocellular carcinoma (HCC), where it is linked to tumor aggressiveness and poor patient outcomes.
- Histone methylation, specifically the increase in H4K20me3, was found to be significant in HCC tissues compared to non-cancerous liver tissues and associated with tumor recurrence and survival rates.
- Experimental findings showed that reactive oxygen species (ROS) lead to increased H4K20me3 and promote epithelial-mesenchymal transition (EMT) in HCC cells, enhancing their migration and invasiveness, while inhibiting H4K20me3 reduced these aggressive behaviors.