Publications by authors named "A Sanchez-Rodriguez"
Objective: The 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria score (≥20 points) has been associated with poor outcomes. We aimed to evaluate its utility as a predictor for mortality and hospitalisation and to derive and validate an ominosity score based on the SLE classification criteria set.
Methods: Incident patients with SLE in a population-based cohort were included.
Article Synopsis
- Protamines are proteins vital for sperm chromatin condensation, with their expression ratios linked to fertility in different species.
- The study aimed to evaluate RNA quality and protamine gene expression in testis samples from wild-derived mice, preserved under various conditions over different time frames.
- Results indicated that samples preserved in RNAlater® or NAP buffer at -80°C maintained RNA integrity and protamine expression effectively, even under less optimal conditions like room temperature for a week.
Effect of Probiotics on Sperm Quality in the Adult Mouse.
Probiotics Antimicrob Proteins
October 2024
Article Synopsis
- Probiotics have recently gained attention for their potential therapeutic effects, but their impact on reproductive health remains under-researched.
- This study tested the effects of two probiotic mixtures on sperm quality in mice, comparing them to a control group that received physiological serum.
- Results indicated that probiotic treatments resulted in a higher percentage of normal sperm and altered head shape, although they didn't significantly improve overall motility compared to controls, suggesting further research is needed.
Bioenergetics plays a crucial role in sperm functions, including motility, capacitation-related protein modifications, oocyte recognition and interaction, all of which are essential for fertilization. Sperm metabolism is recognized as flexible, responding to environmental cues and energetic demands during ejaculation, the journey along the female tract, and until fertilization. Recent studies suggest that sperm metabolic functions are relevant beyond fertilization and may influence zygote and embryo development, impacting paternal-derived effects on offspring development and health.
View Article and Find Full Text PDFClinical Presentation, Care Pathways, and Delays in Access to Specialized Care in Patients With Systemic Lupus Erythematosus: A Study From Lupus Midwest Network (LUMEN).
Arthritis Care Res (Hoboken)
October 2024
Objective: We aimed to characterize presentation and care pathways of patients with systemic lupus erythematosus (SLE), and delays in access to SLE-specialized care.
Methods: We included patients with incident SLE from the Lupus Midwest Network registry. Time from the first medical encounter for SLE clinical manifestation to access to SLE-specialized care, physician diagnosis, and treatment was estimated.