Publications by authors named "A Sanchez-Pozo"
[Selection of pharmacogenomic variants and methodology for their use in community pharmacy].
Farm Comunitarios
October 2024
Regulatory agencies such as the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recognize pharmacogenetics as a key tool in their pharmacological guidelines for pharmaceutical counseling. In this context, community pharmacies play a crucial role in addressing this healthcare need, which could lead to a significant improvement in patients' quality of life by preventing ineffective or contraindicated treatments.In this work, we conducted a systematic review of the available scientific evidence regarding druggene interactions relevant to community pharmacy.
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- PRC2, particularly its subunit EZH2, is found to regulate how carcinoma cells change their characteristics by influencing their states between epithelial and mesenchymal forms.
- EZH2 plays a crucial role during the epithelial-mesenchymal transition (EMT) by repressing mesenchymal genes in lung cancer and plays a similar role in breast cancer.
- This research suggests that the PRC2 mechanism for controlling genes related to cell movement and transition is conserved across different types of carcinomas, highlighting its importance in cancer progression.
Objective: The aim of this article was to perform a narrative review of how pharmacogenetics and pharmacogenomics is being applied in the clinics, especially in Spain.
Method: Publications and websites of major interest have been reviewed.
Results: Pharmacogenes and variants used in several hospitals, available methodologies, and the implementation process are discussed.
Objective: The aim of this article is to perform a narrative review of how pharmacogenetics and pharmacogenomics is being applied in the clinic, especially in Spain.
Method: Publications and websites of major interest have been reviewed.
Results: Pharmacogenes and variants used in several hospitals, available methodologies, and the implementation process are discussed.
An adverse intrauterine or periconceptional environment, such as hyperglycemia during pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this study, we explored the epigenetic profile in maternal peripheral blood samples through pregnancy to find potential epigenetic biomarkers for gestational diabetes mellitus (GDM), as well as candidate genes involved in GDM development. We performed an epigenome-wide association study in maternal peripheral blood samples in 32 pregnant women (16 with GDM and 16 non-GDM) at pregnancy week 24-28 and 36-38.
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