Evidence of Calcium Signaling and Modulation of the LmrS Multidrug Resistant Efflux Pump Activity by Ca Ions in .

Calcium ions (Ca) play a pivotal role in eukaryote cell signaling and regulate many physiological functions. Although a similar role for Ca in prokaryotes has been difficult to demonstrate, there is increasing evidence for Ca as a cell regulator in bacteria. The purpose of this study was to investigate Ca signaling and the effect of Ca on the s multidrug resistant efflux pump LmrS.

Reality or utopia: eradication of the AIDS epidemic in Guinea-Bissau by 2030.

Objectives: to reflect on the implementation of an integrated strategy to eradicate the Acquired Immunodeficiency Syndrome (AIDS) epidemic in Guinea-Bissau by 2030.

Methods: a reflective study.

Reflection: Guinea-Bissau is a Portuguese-speaking country located in Sub-Saharan Africa, in constant political and economic instability.

Author Correction: Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling HS biomedicine.

The original version of this Article contained an error in the spelling of the author Bin Geng, which was incorrectly given as Bing Geng. This has been corrected in both the PDF and HTML versions of the Article.

Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling HS biomedicine.

Hydrogen sulfide has emerged as a critical endogenous signaling transmitter and a potentially versatile therapeutic agent. The key challenges in this field include the lack of approved hydrogen sulfide-releasing probes for in human exploration and the lack of controllable hydrogen sulfide promoieties that can be flexibly installed for therapeutics development. Here we report the identification of the widely used antithrombotic drug clopidogrel as a clinical hydrogen sulfide donor.

Tuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity building.

The diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resistance. Sequence analysis of a 369 base-pair rpoB locus detected 3.