Publications by authors named "A Sanbe"
To investigate the effect of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) on connective tissue growth factor (CTGF) expression in adult retinal pigment epithelial (ARPE)-19 cells. We also studied the inhibitory effect of K-975, a new pan-transcriptional enhanced associate domain (TEAD) inhibitor, and luteolin, a plant-derived flavonoid on CTGF expression. ARPE-19 cells were transfected with either YAP or TAZ overexpression plasmid or treated with transforming growth factor (TGF)-β.
View Article and Find Full Text PDFModification of cardiac disease by transgenically altered histone deacetylase 6.
Biochem Biophys Res Commun
November 2022
Histone deacetylase 6 (HDAC6) is known to deacetylate amino acid lysine in alpha-tubulin. However, the functional role of HDAC6 in the progression of cardiac disease remains uncertain. The functional role of HDAC6 in the hearts was examined using transgenic (TG) mice expressing either human wild-type HDAC6, deacetylase inactive HDAC6 (HDAC6), and human HDAC6 replaced all serine or threonine residues with aspartic acid at N-terminal 1- 43 amino acids (HDAC6) specifically in the hearts.
View Article and Find Full Text PDFArticle Synopsis
- Research shows that SGLT1 contributes to cognitive impairment associated with small vessel disease, and the study aims to investigate if SGLT1 inhibitors can improve this impairment.
- The study used two SGLT1 inhibitors, mizagliflozin and phlorizin, on mice with induced small vessel disease, revealing that phlorizin improved cerebral blood flow while both inhibitors enhanced cognitive function in tests.
- Findings indicate that both inhibitors can reduce negative effects of small vessel disease on cognition, with phlorizin also normalizing certain gene expressions related to inflammation and cell death.
Atrial fibrillation (AF) is a relatively common complication of hypertension. Chronic hypertension induces cardiac HDAC6 catalytic activity. However, whether HDAC6 activation contributes to hypertension-induced AF is still uncertain.
View Article and Find Full Text PDFObjectives: Serotonin (5-hydroxytryptamine; 5-HT) plays an important role in milk volume homeostasis in the mammary glands during lactation, and 5-HT in milk also may affect infant development. The aim of this study was to investigate changes in 5-HT concentration in breast milk according to the duration of lactation and evaluate whether the 5-HT concentration varied before and after nursing.
Methods: Healthy nursing Japanese women who had a natural delivery or underwent a cesarean delivery at Iwate Medical University Hospital were included in this study.