Publications by authors named "A San Feliciano"
Article Synopsis
- This study investigates how different characteristics of patients with obstructive sleep apnea (OSA) can predict their response to mandibular advancement devices (MAD) and aims to create a model for treatment efficacy.
- It analyzed 112 patients over six years, categorizing OSA into different phenotypes, with findings indicating that positional-OSA patients had a significantly higher response rate to MAD compared to non-positional patients.
- The results suggest that specific phenotypes, particularly REM-OSA, are less responsive to MAD treatment, highlighting key metrics like hypoxic burden and T90% that are useful in predicting treatment success in OSA patients.
Corneal diseases, a leading cause of global vision impairment, present challenges in treatment due to corneal tissue donor scarcity and transplant rejection. Hydrogel biomaterials in the form of corneal implants for tissue regeneration, while promising, have faced obstacles related to cellular and tissue integration. This study develops and investigates the potential of granular polyrotaxane (GPR) hydrogels as a scaffold for corneal keratocyte growth and transparent tissue generation.
View Article and Find Full Text PDFMonoaminooxidases (MAOs) are important targets for drugs used in the treatment of neurological and psychiatric disorders and particularly on Parkinson's Disease (PD). Compounds containing a trans-stilbenoid skeleton have demonstrated good selective and reversible MAO-B inhibition. Here, twenty-two (Z)-3-benzylidenephthalides (benzalphthalides, BPHs) displaying a trans-stilbenoid skeleton have been synthesised and evaluated as inhibitors of the MAO-A and MAO-B isoforms.
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- Heart failure patients often struggle with fluid overload even when treated with standard diuretics, but combining these with acetazolamide may improve outcomes like fluid removal and overall efficacy of the treatment.
- A literature review analyzed six studies, showing that acetazolamide can positively impact decongestion and urine production in heart failure patients, although many of these studies had small groups and other limitations.
- The review calls for more research to validate the benefits of acetazolamide, compare it with other treatment options, and examine its effects on more diverse heart failure populations, emphasizing its potential role in improving patient care.
Fibrosis of implants remains a significant challenge in the use of biomedical devices and tissue engineering materials. Antifouling coatings, including synthetic zwitterionic coatings, have been developed to prevent fouling and cell adhesion to several implantable biomaterials. While many of these coatings need covalent attachment, a conceptually simpler approach is to use a spontaneous self-assembly event to anchor the coating to a surface.
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