Publications by authors named "A Sambeth"
Roflumilast and cognition enhancement: A translational perspective.
Biomed Pharmacother
December 2024
Cognitive impairment affiliated with neurological disorders has a severe impact on daily life functioning and the quality of life of patients. This is associated with a significant and long-lasting health, social and financial burden, not only for the patients, but also for families and the wider society. However, treatment for cognitive impairment is only available for the indication Alzheimer's disease (AD) and its prodromal stage Mild Cognitive Impairment (MCI), although with major adverse effects, i.
View Article and Find Full Text PDFIntrusive thoughts of negative experiences can pose a threat to our well-being. To some extent, unwanted memories can be intentionally controlled via an executive control mechanism that downregulates the occurrence of intrusions. Mindfulness training can improve executive control.
View Article and Find Full Text PDFArticle Synopsis
- Early health-technology assessment helps in discussing resource allocation for patients with mild cognitive impairment (MCI) and evaluates the potential of roflumilast treatment to maintain cognitive function.
- The study estimated the innovation headroom using a hypothetical 100% effective treatment and found a 7% reduction in the risk of developing dementia compared to usual care in the Netherlands.
- Results showed a net health benefit of 4.2 quality-adjusted life years (QALYs) with roflumilast being potentially cost-effective at €34,000 per QALY, highlighting the need for further research on its impact on dementia onset.
Age Effects on Old/New Recognition Memory Involving Abstract Figures and Non-words.
Front Aging Neurosci
June 2022
Age-related memory problems posit a growing concern in our society. This study investigated the impact of age and memory strength on recognition memory of pre-experimentally unfamiliar abstract figures and non-words. We applied a three-phase old/new recognition memory paradigm and manipulated memory strength as a function of the Levels of Processing (deep vs.
View Article and Find Full Text PDFObjectives: The present study investigated the effects of biperiden, a muscarinic type 1 antagonist, on the recognition performance of pre-experimentally unfamiliar abstract figures and non-words in healthy young volunteers. The aim was to examine whether 4 mg biperiden could model the recognition memory impairment seen in healthy aging.
Methods: A double-blind, placebo-controlled, two-way crossover study was conducted.