Publications by authors named "A Samat"
Myocardial Disarray and Fibrosis across Hypertrophic Cardiomyopathy Stages Associate with ECG Markers of Arrhythmic Risk.
Eur Heart J Cardiovasc Imaging
October 2024
Article Synopsis
- Myocardial disarray, linked to arrhythmia risk, was studied in patients with prehypertrophic sarcomeric variants (SARC+LVH-) and hypertrophic cardiomyopathy (HCM) using diffusion tensor cardiac MRI (DT-CMR).
- Results showed reduced diastolic fractional anisotropy (FA) and prolonged corrected JT intervals (JTc) in both patient groups compared to controls, suggesting that both conditions exhibit signs of myocardial disarray.
- The study highlighted that lower FA and higher extracellular volume (ECV) correlate with prolonged repolarization, and the JT interval proves effective in distinguishing SARC+LVH- patients from controls and linking to HCM-related sudden cardiac death risk.
Article Synopsis
- The study aimed to assess the effectiveness of ECG in detecting cardiac issues in post-hospitalized COVID-19 patients through cardiac magnetic resonance (CMR) imaging.
- Results showed that these patients had significantly more ECG abnormalities compared to healthy controls, yet both groups had similar levels of CMR abnormalities.
- Adding additional analyses on repolarization improved ECG's ability to identify patients with CMR abnormalities and reduced the reliance on sex in the diagnostic process.
T cell activation is critical for an effective immune response against pathogens. However, dysregulation contributes to the pathogenesis of autoimmune diseases, including Juvenile Idiopathic Arthritis (JIA). The molecular mechanisms underlying T cell activation are still incompletely understood.
View Article and Find Full Text PDFThe Eighth Asian National Control Laboratory (NCL) Network meeting, entitled "Biological Products Quality Control and Self-Sufficiency Strategy focusing on plasma-derived medicinal products (PDMPs)" was held in Seoul on 31 August 2023. The participants were NCL experts from Indonesia, Japan, Malaysia, the Philippines, Vietnam, and the Republic of Korea. Special lectures included the PDMPs self-sufficiency strategies of the World Health Organization (WHO) and Indonesian Food and Drug Authority, and a case study on Global Benchmarking Tool (GBT) assessment for vaccines by the Korea Ministry of Food and Drug Safety.
View Article and Find Full Text PDFTissue-engineered polymeric implants are preferable because they do not cause a significant inflammatory reaction in the surrounding tissue. Three-dimensional (3D) technology can be used to fabricate a customised scaffold, which is critical for implantation. This study aimed to investigate the biocompatibility of a mixture of thermoplastic polyurethane (TPU) and polylactic acid (PLA) and the effects of their extract in cell cultures and in animal models as potential tracheal replacement materials.
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