Publications by authors named "A Saleh-Mghir"
Article Synopsis
- This study assessed the impact of fecal microbiota transplantation (FMT) on clearing carbapenemase-producing Enterobacterales (CPE) infections in patients.
- A total of 20 patients were monitored, showing a 20% success rate for complete CPE clearance two weeks post-FMT and 40% at three months, with no significant differences when compared to a control group.
- The analysis indicated that responder patients had a lower level of CPE before FMT and greater diversity in gut bacteria afterwards, suggesting that specific bacterial species may play a role in the success of the treatment.
Background: Understanding COVID-19 outcomes remains a challenge. While numerous biomarkers have been proposed for severity at admission, limited exploration exists for markers during the infection course, especially for the requirement of oxygen therapy. This study investigates the potential of eosinophil count normalization as a predictor for oxygen weaning during the initial wave of the pandemic.
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- - This narrative review focuses on the benefits and precautions of using expired antibiotics amidst ongoing shortages in Europe, evaluating existing research from PubMed/MEDLINE and Google Scholar.
- - It examines the potential effectiveness and risks associated with using expired antibiotics, suggesting that, under proper storage conditions, many solid forms could be safe for use for at least one extra year past their expiration date.
- - The findings emphasize the importance of reassessing expiration dates during drug shortages to ensure better access to effective treatments while minimizing safety concerns.
Objectives: Natural history and treatment of bone infections caused by carbapenemase-producing Enterobacterales (CPE) are poorly defined. We evaluated the effect of treatment on the progression of subacute osteomyelitis in a rabbit model.
Methods: Two isolates were used: a KPC-producing Klebsiella pneumoniae and an Escherichia coli harbouring bla and bla inserts, both susceptible to gentamicin, colistin, fosfomycin, and ceftazidime-avibactam.
Despite significant advancements in material science, surgical site infection (SSI) rates remain high and prevention is key. This study aimed to demonstrate the in vivo safety and antibacterial efficacy of titanium implants treated with a novel broad-spectrum biocidal compound (DBG21) against methicillin-resistant Staphylococcus aureus (MRSA). Titanium (Ti) discs were covalently bound with DBG21.
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