Publications by authors named "A Sala-Vila"
Purpose Of Review: This narrative review includes the latest clinical and preclinical evidence on fatty acid exposure and telomere length, a widely accepted hallmark of aging.
Recent Findings: A large body of literature focused on n-3 (omega-3) polyunsaturated fatty acids (PUFAs). Observational studies reported beneficial associations with telomere length for self-reported consumption of n-3 PUFA-rich foods; for estimated intake of n-3 PUFAs; and for n-3 PUFAs blood-based biomarkers in most (but not all) studies involving lipidomics, a promising tool in the field.
Article Synopsis
- The study investigates the relationship between different types of n-6 polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA), and mortality rates from various causes in a large UK Biobank cohort of over 257,000 individuals.
- Findings indicate that higher levels of LA are linked to reduced total mortality risk, while higher levels of non-LA n-6 PUFAs are associated with increased mortality risk, particularly from non-cardiovascular and non-cancer causes.
- The research emphasizes that LA and non-LA n-6 PUFAs should not be treated the same when evaluating health impacts, highlighting the importance of maintaining or increasing LA intake for better health outcomes.
Introduction: Brain glucose hypometabolism is a preclinical feature of Alzheimer's disease (AD). Dietary omega-3 fatty acids promote brain glucose metabolism, but clinical research is incipient. Circulating omega-3s objectively reflect their dietary intake.
View Article and Find Full Text PDFIntroduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.
Methods: A total of 1520 participants from the ALFA cohort were included.
Article Synopsis
- In 2016, the first global map of n3 PUFA (Omega-3) levels was created using the Omega-3 Index (O3I), which measures the percentage of EPA and DHA in red blood cell membranes.
- The current study updated this map by including new data from studies conducted after 1999, resulting in a comprehensive analysis of 342,864 subjects across 48 countries.
- Overall, most countries had low to very low O3I levels, with some notable improvements or declines compared to the 2016 map, highlighting specific countries that showed changes in their Omega-3 status.