Publications by authors named "A Sakharova"
Acid-related diseases (ARD) are the most common among digestive diseases. The main goals of therapy of ARD are to reduce the influence of aggression factors (production of HCl, pepsin) and increase the protective properties of the mucous membrane of the upper digestive tract. Also currently in medicine, one of the therapeutic and preventive methods is the use of chloride-hydrocarbonate sodium boron mineral waters.
View Article and Find Full Text PDFRole of pulsatile growth hormone (GH) secretion in the regulation of lipolysis in fasting humans.
Clin Diabetes Endocrinol
February 2022
Background: The increase in growth hormone (GH) secretion during a prolonged fast stimulates lipolytic rate, thereby augmenting the mobilization of endogenous energy at a time when fuel availability is very low.
Study Aim: To identify the specific component of GH secretory pattern responsible for the stimulation of lipolytic rate during fasting in humans.
Study Protocol: We measured lipolytic rate (using stable isotope dilution technique) after an overnight fast in 15 young, healthy, non-obese subjects (11 men and 4 women), and again on four separate occasions after a 59 h fast.
Background: Transsphenoidal surgery is the standard approach for treating Cushing disease. Evidence is needed to document effectiveness.
Objective: To analyze results of transsphenoidal surgery in 276 consecutive patients, including 19 children.
Pheochromocytoma is a rare adrenal gland tumor that is often difficult for physicians to diagnose because of its general, nonspecific complaints. Diagnosis is particularly difficult in patients with neurofibromatosis 1, because pheochromocytoma in these patients will mimic other cardiovascular abnormalities. The authors report the case of a 60-year-old woman with an extensive history of hyperlipidemia, malignant hypertension, coronary artery disease, and neurofibromatosis 1 who was referred for an elective cardiac catheterization as a result of an abnormal stress test.
View Article and Find Full Text PDFArticle Synopsis
- CADASIL is a hereditary cerebrovascular disease linked to specific mutations in the Notch3 gene, affecting the body's small blood vessels.
- Researchers sequenced the Notch3 gene in 30 Russian patients showing CADASIL symptoms and discovered 16 mutations, including 4 that were previously unreported.
- About 60% of those suspected of having CADASIL were confirmed through genetic testing, highlighting the importance of thorough clinical assessments to identify patients likely to have these mutations.